2) Psycho Mantis – Metal Gear Solid
Metal Gear Solid has a great number of tremendously memorable villians but Psycho Mantis set the bar early and set it very high indeed. Possessing psychic powers and using them for evil, Psycho Mantis can possess the main character’s girlfriend and can also anticipate your every move. The only way to defeat Psycho Mantis is to actually plug your controller into another port, making even the most jaded player scratch their head and reconsider their relationship with the game. Deliciously meta.